Hazardous chemicals

The Institute's work consists of better understanding, measuring, characterising and predicting the hazardous properties of chemical substances, alone and in mixtures, and electromagnetic fields (EMFs), as well as their behaviour in humans and the environment, but also when used in industrial processes and during transport
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INERIS's expertise in chemical substances is based on a "hazard-risk-impact" assessment approach and multidisciplinary skills (toxicology, ecotoxicology, dispersion, fire, explosion, environmental economics) that enable it to combine both a "substance" and an "environment" approach. 
INERIS conducts tests using numerical simulation (in silico), at the cellular level (in vitro), and on living beings – mainly rodents and fish (in vivo). The latter are supported by substantial platforms such as fish and rodent animal facilities. These are complemented by biological testing laboratories, chemical and physical analysis laboratories, and facilities more specific to the characterisation of physical hazards (fires, explosions) and a platform specifically designed for the study of nanomaterials and other toxic substances (S-Nano). 
Ineris teams are also involved in the safe transport of dangerous goods (RID/ADR directives, including pipelines and the safe use of chemicals (CLP regulation)). In addition, Ineris is the only public body with expertise in assessing explosives and pyrotechnic articles for civil use. 
INERIS also conducts work on defining environmental guideline values*, which serve as a reference for the aquatic environment and related environmental compartments.
Since 2009, the Chemical Substances Portal has been disseminating information on the physical, chemical, toxicological, ecotoxicological and technical-economic properties of various chemical substances.

Participation in agencies

INERIS participates in the work of national, European and international agencies to assess and categorise the hazards and risks associated with chemicals, in particular ANSES, the European Chemicals Agency (ECHA), the thematic centres of the European Environment Agency, the Eionet network, the OECD and national and international standardisation committees.
As part of the work carried out within the OECD, INERIS teams have been responsible for coordinating France's national activities for test guidelines for more than fifteen years. The Institute itself is involved in the development of new biological tests, in , the publication of guideline 250 (EASZY test for the characterisation of endocrine disrupting potential (EDP)) in 2021. It also contributes to comitology and circular testing organised within the framework of PEPPER (national platform for the pre-validation of tests designed to characterise EPs).
INERIS coordinates or participates in numerous national and European research projects on the assessment of chemical hazards and is able to offer industry high value-added services ranging from hazard characterisation to technical and economic analysis of substitution opportunities.
With this experience, the Institute supports the French public authorities on these issues and contributes to national plans and programmes such as the PNSQA*, PNSE4*, SNPE2*, and the European PARC programme* . The Institute is also responsible for France's national assistance service, which each member country makes available to manufacturers and importers to support industry (particularly SMEs) in implementing the REACH, CLP and POP regulations. 

Research

In terms of research, INERIS contributes to the development of new methodological approaches (NAM) for hazard characterisation, particularly computational approaches (internal exposome for the interpretation of data from large cohorts, toxicokinetic modelling, QSAR, QSPR, (q)AOP, etc.), bioassays, in vitro tools and integrated testing strategies (particularly for EPs). 
Since early 2025, the Institute has been coordinating the European project NAMWISE ( ) , which aims to promote the use of NAMs in the (eco)toxicological hazard assessment of chemicals and in the efficacy of pharmaceuticals, which is currently based on the use of in vivo data.  It brings together 18 partners from eight different countries, including academics, NAM developers and users, and regulatory assessors.
In toxicology, INERIS is focusing on the pulmonary effects of particles and the neurodevelopmental effects of substances and EMFs. 
 


* An environmental guideline value for aquatic environments is the threshold concentration of a pollutant in water, sediment or biota that should not be exceeded in order to protect aquatic ecosystems and human health.
* PNSQA: National Ambient Air Quality Monitoring Plan
* PNSE 4: Fourth National Health and Environment Plan
* SNPE2: National Strategy on Endocrine Disruptors 2
* PARC: Horizon Europe programme initiative on the assessment of risks of chemicals for regulatory purposes