Launch of the Persée Project: A New Approach to the Ecotoxicology of Persistent Substances

Unlike traditional approaches, which are generally limited to short-term exposures, Persée proposes to incorporate multigenerational experiments in the nematode (C. elegans) to better characterize the chronic effects of contaminants. This strategy aims to detect delayed impacts and to better understand the adaptive dynamics of exposed populations. The project focuses on TFA (trifluoroacetic acid), a persistent substance widely present in the environment, whose long-term ecotoxicological effects remain poorly documented. By integrating temporal and evolutionary dimensions, Persée aims to shift ecotoxicology practices toward approaches that better represent real-world environmental conditions. The project will thus contribute to the development of new toxicity indicators that account for cumulative effects and the adaptive capacities of populations across generations.